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3′,4′-Didehydro-3′-deoxyuridine 

Characterisation

CAS: 386264-46-6

IUPAC Name: 1-((2R,3R)-3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Other names: DdhU, Ddh-U, 3′,4′-Didehydro-3′-deoxyuridine (ACI)

Molecular weight: 226.19 g/mol

Molecular formula: C₉H₁₀N₂O₅

InChI: InChI=1S/C9H10N2O5/c12-4-5-3-6(13)8(16-5)11-2-1-7(14)10-9(11)15/h1-3,6,8,12-13H,4H2,(H,10,14,15)/t6-,8-/m1/s1

Description

3′,4′-Didehydro-3′-deoxyuridine is an analogue of uridine. A related compound,  3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

References

• https://doi.org/10.1016/j.tetlet.2010.10.117
• US3457255 A 1969-07-22
• WO2022038539 A2 2022-02-24

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This product was developed in the grant programme Czech Rise Up 3.0 – Výzkum medicínských řešení v době digitalizace funded by the European Union.