3′,4′-Didehydro-3′-deoxyuridine triphosphate – CAS 2499590-38-2

31005900

3′,4′-Didehydro-3′-deoxyuridine triphosphate – CAS 2499590-38-2 is synthesized by Santiago Lab (Prague, Czech Republic)

Purity (LC-MS)

min 95%

Package contents

3′,4′-Didehydro-3′-deoxyuridine triphosphate triethylammonium salt

This compound is for research use only. We do not sell to patients.
SizeAvailabilityPriceQuantity
1 mg

In stock

3100
5 mg

In stock

5900

3′,4′-Didehydro-3′-deoxyuridine triphosphate – CAS 2499590-38-2

Characterisation

CAS: 2499590-38-2, 2787607-83-2 (Et3NH+ salt)

IUPAC Name: ((4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-4,5-dihydrofuran-2-yl)methyl tetrahydrogen triphosphate

Other names: DdhU-TP, Ddh-U triphosphate, 3′,4′-Didehydro-3′-deoxyuridine triphosphate

Molecular weight: 466.12 g/mol

Molecular formula: C9H13N2O14P3

InChI: InChI=1S/C9H13N2O14P3/c12-6-3-5(23-8(6)11-2-1-7(13)10-9(11)14)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-3,6,8,12H,4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t6-,8-/m1/s1

Description

3′,4′-Didehydro-3′-deoxyuridine triphosphate is a metabolite of 3′,4′-Didehydro-3′-deoxyuridine (DdhU). A related compound,  3′,4′-didehydro-3′-deoxycytidine triphosphate has been proven to have antiviral properties. It has the ability to prevent the replication of several viruses, including the Zika virus. This molecule is naturally produced in mammals through the dehydration of cytidine triphosphate (CTP), which is catalyzed by the enzyme viperin.

References

  • WO2021133854 A1 2021-07-01
  • WO2020202142 A2 2020-10-08
  • WO2022123501 A1 2022-06-16

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