IUPAC Name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl 2-methylpropanoate
Other names: EIDD 2801, Uridine-5′-methylpropanoate-4-oxime, Lagevrio, MK-4482, prodrug-EIDD-1931
Molecular weight: 329.31 g/mol
Molecular formula: C13H19N3O7
Molnupiravir is used as a prodrug. It breaks down into a free ribonucleoside derivative inside the cell, and kinases convert the nucleoside into its relative 5‘-O-triphosphate, responsible for antiviral activity. The 5′-O-triphosphate (β-D–N4-4-Hydroxycytidine 5′-triphosphate, EIDD-1931 5′-triphosphate or NHC-TP) is incorporated into the nascent viral RNA by RNA polymerase, causing mutations and the consequent extinction of the virus. This effect is generally called lethal mutagenesis. Molnupiravir can change its structure by tautomerism between a uridine-like form and a cytidine-like form and thus disguise itself from the virus, providing an advantage over other antiviral agents to which some viruses can develop resistance over time.
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