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N⁴-Hydroxycytidine diphosphate– CAS 39023-73-9

Characterisation

CAS: 39023-73-9

IUPAC Name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl trihydrogen diphosphate

Other names: N4-OH-CDP, NHC-diphosphate

Molecular weight: 419.18 g/mol

Molecular formula: C₉H₁₅N₃O₁₂P₂

Description

N⁴-Hydroxycytidine diphosphate– CAS 39023-73-9 is a metabolite of molnupiravir. The 5′-O-triphosphate (β-_D–N⁴-4-Hydroxycytidine 5′-triphosphate, EIDD-1931 5′-triphosphate or NHC-TP) is incorporated into the nascent viral RNA by RNA polymerase, causing mutations and the consequent extinction of the virus. This effect is generally called lethal mutagenesis. Molnupiravir can change its structure by tautomerism between a uridine-like form and a cytidine-like form and thus disguise itself from the virus, providing an advantage over other antiviral agents to which some viruses can develop resistance over time.

You can read more about Molnupiravir in our article.

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