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N⁴-Hydroxycytidine monophosphate– CAS 4988-54-9

Characterisation

CAS: 4988-54-9

IUPAC Name: [(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyamino)-2-oxopyrimidin-1-yl]oxolan-2-yl]methyl dihydrogen phosphate

Other names: N4-OH-CMP, N-Hydroxycytidine 5′-(Dihydrogen Phosphate), Molnupiravir monophosphate

Molecular weight: 339.20 g/mol

Molecular formula:C₉H₁₄N₃O₉P

Description

N⁴-Hydroxycytidine monophosphate– CAS 4988-54-9 is a metabolite of molnupiravir. The 5′-O-triphosphate (β-_D–N⁴-4-Hydroxycytidine 5′-triphosphate, EIDD-1931 5′-triphosphate or NHC-TP) is incorporated into the nascent viral RNA by RNA polymerase, causing mutations and the consequent extinction of the virus. This effect is generally called lethal mutagenesis. Molnupiravir can change its structure by tautomerism between a uridine-like form and a cytidine-like form and thus disguise itself from the virus, providing an advantage over other antiviral agents to which some viruses can develop resistance over time.

You can read more about Molnupiravir in our article.

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