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Tenofovir monophosphate – CAS 206646-04-0

Characterisation

CAS: 206646-04-0

IUPAC Name: [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phosphonooxyphosphinic acid

Other names: Tenofovir phosphate, PMPA-monophosphate,

Molecular weight: 367.19 g/mol

Molecular formula: C₉H₁₅N₅O₇P2

InChI: InChI=1S/C9H15N5O7P2/c1-6(20-5-22(15,16)21-23(17,18)19)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H,15,16)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1

Description

Tenofovir monophosphate is a metabolite of tenofovir. Tenofovir is a nucleotide analog reverse-transcriptase inhibitor (NtRTI). It selectively inhibits viral reverse transcriptase, a crucial enzyme in retroviruses such as human immunodeficiency virus (HIV), while showing limited inhibition of human enzymes, such as DNA polymerases α, β, and mitochondrial DNA polymerase γ.

References

• https://doi.org/10.1021/mp900036s
• https://doi.org/10.1371/journal.pone.0195764
• https://doi.org/10.1089/aid.2012.0089

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