Archives

Yamaguchi reagent – Reagent of the month June

June 14, 2023|Reagent of the Month | 2 Min Read

Yamaguchi reagent – Reagent of the month June 2,4,6-trichlorobenzoyl chloride (TCBCl), also known as Yamaguchi reagent (Figure 1) is a reagent that is employed in an esterification process devised by […]

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Reagent of the month – April- Tebbe and Petasis reagents

April 20, 2023|Reagent of the Month | 3 Min Read

Tebbe and Petasis reagents μ-Chloro[di(cyclopenta-2,4-dien-1-yl)]dimethyl(μ-methylene)titaniumaluminum (Tebbe reagent, Figure 1) is an organometallic reagent used to methylenation of carbonyl compounds. The main advantage of the Tebbe reagent over the traditional Wittig […]

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Reagent of the month – March – Seyferth-Gilbert and Bestmann-Ohira reagents

March 22, 2023|Reagent of the Month | 3 Min Read

Reagent of the month – March – Seyferth-Gilbert and Bestmann-Ohira reagents Dimethyl(1-diazomethyl)phosphonate (Seyferth–Gilbert reagent, Figure 1) is a homologation reagent used to convert aryl ketones and some aldehydes into alkynes […]

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Reagent of the month – Amberlyst 15 ® resin

January 2, 2023|Reagent of the Month | 4 Min Read

Reagent of the month – Amberlyst 15 ® resin Many synthetic applications use acidic catalysis, but having an extra compound in solution to serve as a catalyst, such as TsOH […]

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Reagent of the month – November – Langlois reagent

November 30, 2022|Reagent of the Month | 2 Min Read

Reagent of the month – November – Langlois reagent Trifluormehylation is an effective technique to increase drug candidate solubility and lipophilicity, and so strategies for adding the CF3 group are […]

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DDQ – reagent of the month – October

October 13, 2022|Reagent of the Month | 3 Min Read

Reagent of the month – DDQ and quinone-derived oxidants Reagents derived from p-quinone such as 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) or p-chloranil are used in a wide range of applications in organic synthesis […]

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Reagent of the month – March- DMTMM

March 7, 2022|Reagent of the Month | 5 Min Read

DMTMM in amide bond formation Amide bond formation is one the most widely occurring reactions in organic chemistry as well as in drug development. There are numerous ways to synthesize […]

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