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Schwartz’s reagent – Reagent of the month August
Schwartz’s reagent – Reagent of the month August Zirconocene chloride hydride (Schwartz’s reagent, Figure 1) is an organozirconium compound used in a wide range of organic reactions. Preparation of Schwartz’s […]
Yamaguchi reagent – Reagent of the month June
Yamaguchi reagent – Reagent of the month June 2,4,6-trichlorobenzoyl chloride (TCBCl), also known as Yamaguchi reagent (Figure 1) is a reagent that is employed in an esterification process devised by […]
Reagent of the month – April- Tebbe and Petasis reagents
Tebbe and Petasis reagents μ-Chloro[di(cyclopenta-2,4-dien-1-yl)]dimethyl(μ-methylene)titaniumaluminum (Tebbe reagent, Figure 1) is an organometallic reagent used to methylenation of carbonyl compounds. The main advantage of the Tebbe reagent over the traditional Wittig […]
Reagent of the month – March – Seyferth-Gilbert and Bestmann-Ohira reagents
Reagent of the month – March – Seyferth-Gilbert and Bestmann-Ohira reagents Dimethyl(1-diazomethyl)phosphonate (Seyferth–Gilbert reagent, Figure 1) is a homologation reagent used to convert aryl ketones and some aldehydes into alkynes […]
Reagent of the month – CBS oxazaborolidine
Reagent of the month – CBS oxazaborolidine The Corey-Bakshi-Shibata (CBS) catalyst is an organocatalyst that is used in asymmetric ketone reductions (Corey-Itsuno reduction). The structure of the CBS oxazaborolidine catalyst […]
An introduction to RNA caps
An introduction to RNA caps Protein synthesis is a critical biological process that is divided into two parts. A segment of DNA encoding a specific protein (a gene) is copied […]
Reagent of the month – Amberlyst 15 ® resin
Reagent of the month – Amberlyst 15 ® resin Many synthetic applications use acidic catalysis, but having an extra compound in solution to serve as a catalyst, such as TsOH […]
Reagent of the month – November – Langlois reagent
Reagent of the month – November – Langlois reagent Trifluormehylation is an effective technique to increase drug candidate solubility and lipophilicity, and so strategies for adding the CF3 group are […]
Introduction to antibody-drug conjugates (ADCs)
Introduction to antibody-drug conjugates (ADCs) The selectivity of therapeutic drugs to cancer cells over healthy tissue is one of the most challenging difficulties in cancer treatment. The employment of sophisticated […]
DDQ – reagent of the month – October
Reagent of the month – DDQ and quinone-derived oxidants Reagents derived from p-quinone such as 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) or p-chloranil are used in a wide range of applications in organic synthesis […]