Archives

Antibacterial triphosphates: different use of nucleoside analogues

August 15, 2022|Antivirals | 5 Min Read

Antibacterial triphosphates: different use of nucleoside analogues1 In the last years, and especially during the SARS-Co-2 pandemic, giant efforts were devoted to designing, synthesising and studying antiviral agents. On the […]

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Contract research organization- Santiago lab

June 27, 2022|Managment | 5 Min Read

What does a contract research organization mean?   A contract research organization (CRO) is a company that provides its solutions and expertise to other companies ranging from pharmaceutical, biotechnology or […]

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Why are nucleoside triphosphates so important?

May 9, 2022|Uncategorized | 4 Min Read

Triphosphates of nucleoside-based antiviral drugs Nucleoside analogues are the largest class of antiviral agents based on small molecules. Nowadays, they are the cornerstone of chemotherapy for several viral chronic infections, […]

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Reagents of the month- April- Lawesson’s and Woollins’ reagents

April 19, 2022|Uncategorized | 3 Min Read

Lawesson’s reagent Many biologically active substances contain a sulphur atom; however, it is usually not so easy to introduce sulphur into the molecule. Therefore, several thionation reagents were developed in […]

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Santiago’s Case Study: Antiviral Kit

April 5, 2022|Antivirals | 4 Min Read

Research in a time of COVID-19 When a thousand people worldwide suffered from lethal coronavirus (COVID-19) in 2020, we came up with an ambitious project to contribute to the worldwide […]

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Custom synthesis – Santiago lab

March 15, 2022|Managment | 5 Min Read

How are custom synthesis projects done at Santiago?   Custom synthesis can be beneficial in many ways. These days many researchers from various fields require specialised chemical reagents– starting building […]

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Reagent of the month – March- DMTMM

March 7, 2022|Reagent of the Month | 5 Min Read

DMTMM in amide bond formation Amide bond formation is one the most widely occurring reactions in organic chemistry as well as in drug development. There are numerous ways to synthesize […]

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Paxlovid- history and mechanism of action

February 23, 2022|Uncategorized | 3 Min Read

Paxlovid (Nirmatrelvir/Ritonavir) Paxlovid is a new potential drug for COVID-19 invented by Pfizer. Paxlovid is composed of two active ingredients, Nirmatrelvir and Ritonavir. Similarly, a mixture of Lopinavir and Ritonavir […]

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New Nucleoside Triphosphates with Antiviral Activity

February 3, 2022|Antivirals, Triphosphates | 5 Min Read

Nucleoside triphosphates with antiviral activity Viruses are causing many troubles in our lives these days. They cause many serious diseases (some of them even deadly) such as cold, influenza, EBOLA, […]

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Alaptide – history, biological activity and synthesis

January 19, 2022|Alaptide | 9 Min Read

Version in Czech is bellow the English version/ Verze v češtině se nachází pod anglickým textem Alaptide Many unique and interesting organic compounds were developed and synthesised by Czech and […]

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