Archives

SnAP Reagents- Introduction SnAP (Stannane Amine Protocol) reagents are a class of organotin building blocks for synthesis of saturated N-heterocycles that often find use in medicinal chemistry in one step […]

Evans oxazolidinones Evans oxazolidinones are a class of chiral auxiliaries discovered by David A. Evans in 1982 for stereoselective alpha alkylation reactions (https://doi.org/10.1021/ja00370a050), but their applications have expanded significantly since […]

Schwartz’s reagent – Reagent of the month August Zirconocene chloride hydride (Schwartz’s reagent, Figure 1) is an organozirconium compound used in a wide range of organic reactions. Preparation of Schwartz’s […]

Reagent of the month – CBS oxazaborolidine The Corey-Bakshi-Shibata (CBS) catalyst is an organocatalyst that is used in asymmetric ketone reductions (Corey-Itsuno reduction). The structure of the CBS oxazaborolidine catalyst […]

Introduction to antibody-drug conjugates (ADCs) The selectivity of therapeutic drugs to cancer cells over healthy tissue is one of the most challenging difficulties in cancer treatment. The employment of sophisticated […]

Triphosphates of nucleoside-based antiviral drugs Nucleoside analogues are the largest class of antiviral agents based on small molecules. Nowadays, they are the cornerstone of chemotherapy for several viral chronic infections, […]

Lawesson’s reagent Many biologically active substances contain a sulphur atom; however, it is usually not so easy to introduce sulphur into the molecule. Therefore, several thionation reagents were developed in […]

Paxlovid (Nirmatrelvir/Ritonavir) Paxlovid is a new potential drug for COVID-19 invented by Pfizer. Paxlovid is composed of two active ingredients, Nirmatrelvir and Ritonavir. Similarly, a mixture of Lopinavir and Ritonavir […]