SnAP Reagents- January- Reagent of the month

January 31, 2024|Uncategorized | 2 Min Read

SnAP Reagents- Introduction SnAP (Stannane Amine Protocol) reagents are a class of organotin building blocks for synthesis of saturated N-heterocycles that often find use in medicinal chemistry in one step […]

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Reagent of the month November– Evans oxazolidinones

November 20, 2023|Uncategorized | 3 Min Read

Evans oxazolidinones Evans oxazolidinones are a class of chiral auxiliaries discovered by David A. Evans in 1982 for stereoselective alpha alkylation reactions (, but their applications have expanded significantly since […]

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Schwartz’s reagent – Reagent of the month August

August 14, 2023|Uncategorized | 3 Min Read

Schwartz’s reagent – Reagent of the month August Zirconocene chloride hydride (Schwartz’s reagent, Figure 1) is an organozirconium compound used in a wide range of organic reactions. Preparation of Schwartz’s […]

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Reagent of the month – CBS oxazaborolidine

February 16, 2023|Uncategorized | 3 Min Read

Reagent of the month – CBS oxazaborolidine The Corey-Bakshi-Shibata (CBS) catalyst is an organocatalyst that is used in asymmetric ketone reductions (Corey-Itsuno reduction). The structure of the CBS oxazaborolidine catalyst […]

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Introduction to antibody-drug conjugates (ADCs)

November 22, 2022|Uncategorized | 4 Min Read

Introduction to antibody-drug conjugates (ADCs) The selectivity of therapeutic drugs to cancer cells over healthy tissue is one of the most challenging difficulties in cancer treatment. The employment of sophisticated […]

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Why are nucleoside triphosphates so important?

May 9, 2022|Uncategorized | 4 Min Read

Triphosphates of nucleoside-based antiviral drugs Nucleoside analogues are the largest class of antiviral agents based on small molecules. Nowadays, they are the cornerstone of chemotherapy for several viral chronic infections, […]

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Reagents of the month- April- Lawesson’s and Woollins’ reagents

April 19, 2022|Uncategorized | 3 Min Read

Lawesson’s reagent Many biologically active substances contain a sulphur atom; however, it is usually not so easy to introduce sulphur into the molecule. Therefore, several thionation reagents were developed in […]

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Paxlovid- history and mechanism of action

February 23, 2022|Uncategorized | 3 Min Read

Paxlovid (Nirmatrelvir/Ritonavir) Paxlovid is a new potential drug for COVID-19 invented by Pfizer. Paxlovid is composed of two active ingredients, Nirmatrelvir and Ritonavir. Similarly, a mixture of Lopinavir and Ritonavir […]

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November 19, 2021|Antivirals, Nucleosides, Triphosphates, Uncategorized | 3 Min Read
Molnupiravir is a new potential drug against the SARS-CoV-2 infectious virus.   To this date, all medications against SARS-CoV-2 are administered only by infusion and only in severe disease cases [...]
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