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Reagent of the month – CBS oxazaborolidine The Corey-Bakshi-Shibata (CBS) catalyst is an organocatalyst that is used in asymmetric ketone reductions (Corey-Itsuno reduction). The structure of the CBS oxazaborolidine catalyst […]

Introduction to antibody-drug conjugates (ADCs) The selectivity of therapeutic drugs to cancer cells over healthy tissue is one of the most challenging difficulties in cancer treatment. The employment of sophisticated […]

Triphosphates of nucleoside-based antiviral drugs Nucleoside analogues are the largest class of antiviral agents based on small molecules. Nowadays, they are the cornerstone of chemotherapy for several viral chronic infections, […]

Lawesson’s reagent Many biologically active substances contain a sulphur atom; however, it is usually not so easy to introduce sulphur into the molecule. Therefore, several thionation reagents were developed in […]

Paxlovid (Nirmatrelvir/Ritonavir) Paxlovid is a new potential drug for COVID-19 invented by Pfizer. Paxlovid is composed of two active ingredients, Nirmatrelvir and Ritonavir. Similarly, a mixture of Lopinavir and Ritonavir […]