Archives

Antiviral drugs

December 13, 2021|Antivirals, Nucleosides, Triphosphates | 8 Min Read

Viruses are pathogens occurring all around us that can be fought with antiviral drugs. Viruses are the cause of a large number of diseases, many of which are deadly – […]

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Automated DNA chemical synthesis

December 6, 2021|Nucleosides | 3 Min Read

Automated DNA chemical synthesis Over the last few decades, several approaches have been developed to synthesise short DNA sequences. Relevant approaches include the phosphodiester method and the H-phosphonate method. However, […]

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Islatravir

November 26, 2021|Nucleosides, Triphosphates | 4 Min Read

AIDS is a terminal disease caused by the human immunodeficiency virus (HIV), affecting millions worldwide. HIV belongs to the group of retroviruses, which act by incorporating the genetic information stored [...]

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Molnupiravir

November 19, 2021|Antivirals, Nucleosides, Triphosphates, Uncategorized | 3 Min Read

Molnupiravir is a new potential drug against the SARS-CoV-2 infectious virus. To this date, all medications against SARS-CoV-2 are administered only by infusion and only in severe disease cases [...]

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Nucleotides for DNA post-synthetic functionalization through click chemistry at SantiagoLab

November 3, 2021|Nucleosides, Triphosphates | 4 Min Read

Base-modified DNA could potentially find widespread application in medicinal chemistry and therapy, as well as in material science.[1] Examples of applications of base-modified oligonucleotides include aptamers for therapy[2], as scorpion […]

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Fighting viruses with nucleotide prodrugs at Santiago Lab

October 11, 2021|Antivirals, Nucleosides | 4 Min Read

During the course of the last decades, outstanding efforts were devoted to design and develop nucleotide prodrugs to be employed as potential therapeutic agents, especially for the treatment of human […]

by santiagola