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Paxlovid- history and mechanism of action
Paxlovid (Nirmatrelvir/Ritonavir) Paxlovid is a new potential drug for COVID-19 invented by Pfizer. Paxlovid is composed of two active ingredients, Nirmatrelvir and Ritonavir. Similarly, a mixture of Lopinavir and Ritonavir […]
Alaptide – history, biological activity and synthesis
Version in Czech is bellow the English version/ Verze v češtině se nachází pod anglickým textem Alaptide Many unique and interesting organic compounds were developed and synthesised by Czech and […]
Scale-up at Santiago Lab
Scale-up of organic reactions At Santiago, we have broad experience with the scale-up of various processes. One of the projects we have been working on was purifying 350 kg of […]
Automated DNA chemical synthesis
Automated DNA chemical synthesis Over the last few decades, several approaches have been developed to synthesise short DNA sequences. Relevant approaches include the phosphodiester method and the H-phosphonate method. However, […]
Islatravir
AIDS is a terminal disease caused by the human immunodeficiency virus (HIV), affecting millions worldwide. HIV belongs to the group of retroviruses, which act by incorporating the genetic information stored [...]
Nucleotides for DNA post-synthetic functionalization through click chemistry at SantiagoLab
Base-modified DNA could potentially find widespread application in medicinal chemistry and therapy, as well as in material science.[1] Examples of applications of base-modified oligonucleotides include aptamers for therapy[2], as scorpion […]